Nitrates and Riociguat: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Nitrates and Riociguat unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Nitrates interacts with Riociguat

Both drugs increase nitric oxide-cGMP signaling and produce additive vasodilation. The combination can cause severe symptomatic hypotension.

What you should do

Do not coadminister. Ensure an appropriate washout period before switching between therapies.

Key facts

Severity

Major — avoid combination

Mechanism

Both drugs increase nitric oxide-cGMP signaling and produce additive vasodilation. The combination can cause severe symp...

Action

Do not coadminister. Ensure an appropriate washout period before switching between therapies.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Nitrates and Riociguat together?

No — this combination should generally be avoided. Do not coadminister. Ensure an appropriate washout period before switching between therapies.

What is the severity of this interaction?

The interaction between Nitrates and Riociguat is classified as Major — avoid combination. Both drugs increase nitric oxide-cGMP signaling and produce additive vasodilation. The combination can cause severe symptomatic hypotension.

What should I do if I'm prescribed both?

Do not coadminister. Ensure an appropriate washout period before switching between therapies. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.