Nitrates and Tadalafil: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Nitrates and Tadalafil unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Nitrates interacts with Tadalafil

Tadalafil inhibits phosphodiesterase type 5, increasing cyclic GMP, while nitrates increase nitric oxide-mediated cyclic GMP production. The combined vasodilatory effect can cause profound hypotension.

What you should do

Do not coadminister. Allow an appropriate washout period after tadalafil before giving nitrates.

Key facts

Severity

Major — avoid combination

Mechanism

Tadalafil inhibits phosphodiesterase type 5, increasing cyclic GMP, while nitrates increase nitric oxide-mediated cyclic...

Action

Do not coadminister. Allow an appropriate washout period after tadalafil before giving nitrates.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Nitrates and Tadalafil together?

No — this combination should generally be avoided. Do not coadminister. Allow an appropriate washout period after tadalafil before giving nitrates.

What is the severity of this interaction?

The interaction between Nitrates and Tadalafil is classified as Major — avoid combination. Tadalafil inhibits phosphodiesterase type 5, increasing cyclic GMP, while nitrates increase nitric oxide-mediated cyclic GMP production. The combined vasodilatory effect can cause profound hypotension.

What should I do if I'm prescribed both?

Do not coadminister. Allow an appropriate washout period after tadalafil before giving nitrates. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.