Nitrendipine and Rifampicin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Nitrendipine and Rifampicin unless specifically directed by your doctor.
How Nitrendipine interacts with Rifampicin
Rifampicin strongly induces CYP3A4, accelerating metabolism of dihydropyridine calcium-channel blockers such as nitrendipine. This can markedly reduce antihypertensive efficacy.
What you should do
Avoid the combination where possible and choose an antihypertensive less affected by CYP3A induction. Monitor blood pressure closely if concurrent use cannot be avoided.
Key facts
Severity
Major — avoid combination
Mechanism
Rifampicin strongly induces CYP3A4, accelerating metabolism of dihydropyridine calcium-channel blockers such as nitrendi...
Action
Avoid the combination where possible and choose an antihypertensive less affected by CYP3A induction. Monitor blood pres...
Frequently asked questions
Can I take Nitrendipine and Rifampicin together?
No — this combination should generally be avoided. Avoid the combination where possible and choose an antihypertensive less affected by CYP3A induction. Monitor blood pressure closely if concurrent use cannot be avoided.
What is the severity of this interaction?
The interaction between Nitrendipine and Rifampicin is classified as Major — avoid combination. Rifampicin strongly induces CYP3A4, accelerating metabolism of dihydropyridine calcium-channel blockers such as nitrendipine. This can markedly reduce antihypertensive efficacy.
What should I do if I'm prescribed both?
Avoid the combination where possible and choose an antihypertensive less affected by CYP3A induction. Monitor blood pressure closely if concurrent use cannot be avoided. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.