Nitroglycerin and Tadalafil: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Nitroglycerin and Tadalafil unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Nitroglycerin interacts with Tadalafil

PDE5 inhibitors potentiate the vasodilatory effects of nitric oxide donors by accumulating cyclic GMP in vascular smooth muscle, leading to profound, prolonged hypotension and ischaemia.

What you should do

Combination is contraindicated. Wait at least 48 hours after tadalafil before administering any nitrate; 24 hours after sildenafil or vardenafil.

Key facts

Severity

Major — avoid combination

Mechanism

PDE5 inhibitors potentiate the vasodilatory effects of nitric oxide donors by accumulating cyclic GMP in vascular smooth...

Action

Combination is contraindicated. Wait at least 48 hours after tadalafil before administering any nitrate; 24 hours after ...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Nitroglycerin and Tadalafil together?

No — this combination should generally be avoided. Combination is contraindicated. Wait at least 48 hours after tadalafil before administering any nitrate; 24 hours after sildenafil or vardenafil.

What is the severity of this interaction?

The interaction between Nitroglycerin and Tadalafil is classified as Major — avoid combination. PDE5 inhibitors potentiate the vasodilatory effects of nitric oxide donors by accumulating cyclic GMP in vascular smooth muscle, leading to profound, prolonged hypotension and ischaemia.

What should I do if I'm prescribed both?

Combination is contraindicated. Wait at least 48 hours after tadalafil before administering any nitrate; 24 hours after sildenafil or vardenafil. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.