Selegiline and Sertraline: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Selegiline and Sertraline unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Selegiline interacts with Sertraline

Combined MAO-B inhibition (selegiline) and serotonin reuptake inhibition (sertraline) causes excessive serotonergic activity with risk of serotonin syndrome.

What you should do

Avoid combination. Allow 14-day washout after selegiline before starting sertraline, and 5 weeks after fluoxetine before selegiline.

Key facts

Severity

Major — avoid combination

Mechanism

Combined MAO-B inhibition (selegiline) and serotonin reuptake inhibition (sertraline) causes excessive serotonergic acti...

Action

Avoid combination. Allow 14-day washout after selegiline before starting sertraline, and 5 weeks after fluoxetine before...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Selegiline and Sertraline together?

No — this combination should generally be avoided. Avoid combination. Allow 14-day washout after selegiline before starting sertraline, and 5 weeks after fluoxetine before selegiline.

What is the severity of this interaction?

The interaction between Selegiline and Sertraline is classified as Major — avoid combination. Combined MAO-B inhibition (selegiline) and serotonin reuptake inhibition (sertraline) causes excessive serotonergic activity with risk of serotonin syndrome.

What should I do if I'm prescribed both?

Avoid combination. Allow 14-day washout after selegiline before starting sertraline, and 5 weeks after fluoxetine before selegiline. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.