Ritonavir and Triazolam: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ritonavir and Triazolam unless specifically directed by your doctor.
How Ritonavir interacts with Triazolam
Ritonavir strongly inhibits CYP3A4, the primary clearance pathway for triazolam. Triazolam exposure can increase markedly, causing prolonged sedation and respiratory depression.
What you should do
Avoid coadministration. Use a benzodiazepine less dependent on CYP3A4 metabolism, such as lorazepam, oxazepam, or temazepam, if clinically appropriate.
Key facts
Severity
Major — avoid combination
Mechanism
Ritonavir strongly inhibits CYP3A4, the primary clearance pathway for triazolam. Triazolam exposure can increase markedl...
Action
Avoid coadministration. Use a benzodiazepine less dependent on CYP3A4 metabolism, such as lorazepam, oxazepam, or temaze...
Frequently asked questions
Can I take Ritonavir and Triazolam together?
No — this combination should generally be avoided. Avoid coadministration. Use a benzodiazepine less dependent on CYP3A4 metabolism, such as lorazepam, oxazepam, or temazepam, if clinically appropriate.
What is the severity of this interaction?
The interaction between Ritonavir and Triazolam is classified as Major — avoid combination. Ritonavir strongly inhibits CYP3A4, the primary clearance pathway for triazolam. Triazolam exposure can increase markedly, causing prolonged sedation and respiratory depression.
What should I do if I'm prescribed both?
Avoid coadministration. Use a benzodiazepine less dependent on CYP3A4 metabolism, such as lorazepam, oxazepam, or temazepam, if clinically appropriate. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.