Ritonavir and Tadalafil: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ritonavir and Tadalafil unless specifically directed by your doctor.
How Ritonavir interacts with Tadalafil
Ritonavir potently inhibits CYP3A4, dramatically increasing tadalafil exposure with risk of severe hypotension, syncope, and prolonged erection.
What you should do
Limit tadalafil to 10 mg every 72 hours for erectile dysfunction; avoid daily-dose tadalafil and avoid in pulmonary arterial hypertension indication.
Key facts
Severity
Major — avoid combination
Mechanism
Ritonavir potently inhibits CYP3A4, dramatically increasing tadalafil exposure with risk of severe hypotension, syncope,...
Action
Limit tadalafil to 10 mg every 72 hours for erectile dysfunction; avoid daily-dose tadalafil and avoid in pulmonary arte...
Frequently asked questions
Can I take Ritonavir and Tadalafil together?
No — this combination should generally be avoided. Limit tadalafil to 10 mg every 72 hours for erectile dysfunction; avoid daily-dose tadalafil and avoid in pulmonary arterial hypertension indication.
What is the severity of this interaction?
The interaction between Ritonavir and Tadalafil is classified as Major — avoid combination. Ritonavir potently inhibits CYP3A4, dramatically increasing tadalafil exposure with risk of severe hypotension, syncope, and prolonged erection.
What should I do if I'm prescribed both?
Limit tadalafil to 10 mg every 72 hours for erectile dysfunction; avoid daily-dose tadalafil and avoid in pulmonary arterial hypertension indication. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.