Sacubitril Valsartan and Simvastatin: Drug Interaction Guide

Quick answer: Sacubitril Valsartan and Simvastatin have a minor interaction — typically manageable with awareness.

Interaction severity: Minor — typically manageable

How Sacubitril Valsartan interacts with Simvastatin

Sacubitril-valsartan may inhibit hepatic uptake transporters such as OATP1B1 and OATP1B3. Simvastatin exposure can increase modestly, potentially increasing muscle adverse effects.

What you should do

Monitor for myalgia or weakness, especially after initiation or dose increases. Consider statin dose adjustment if symptoms or creatine kinase elevation occur.

Key facts

Severity

Minor — typically manageable

Mechanism

Sacubitril-valsartan may inhibit hepatic uptake transporters such as OATP1B1 and OATP1B3. Simvastatin exposure can incre...

Action

Monitor for myalgia or weakness, especially after initiation or dose increases. Consider statin dose adjustment if sympt...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Sacubitril Valsartan and Simvastatin together?

Usually yes, with awareness. Monitor for myalgia or weakness, especially after initiation or dose increases. Consider statin dose adjustment if symptoms or creatine kinase elevation occur.

What is the severity of this interaction?

The interaction between Sacubitril Valsartan and Simvastatin is classified as Minor — typically manageable. Sacubitril-valsartan may inhibit hepatic uptake transporters such as OATP1B1 and OATP1B3. Simvastatin exposure can increase modestly, potentially increasing muscle adverse effects.

What should I do if I'm prescribed both?

Monitor for myalgia or weakness, especially after initiation or dose increases. Consider statin dose adjustment if symptoms or creatine kinase elevation occur. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.