Sacubitril and Valsartan: Drug Interaction Guide

Quick answer: Sacubitril and Valsartan have a minor interaction — typically manageable with awareness.

Interaction severity: Minor — typically manageable

How Sacubitril interacts with Valsartan

Although marketed as a fixed combination, when prescribed alongside additional valsartan-containing products there is additive angiotensin II receptor blockade and risk of hypotension, hyperkalemia, and renal impairment.

What you should do

Do not co-prescribe separate ARBs with sacubitril/valsartan combination products; review medication list to avoid therapeutic duplication.

Key facts

Severity

Minor — typically manageable

Mechanism

Although marketed as a fixed combination, when prescribed alongside additional valsartan-containing products there is ad...

Action

Do not co-prescribe separate ARBs with sacubitril/valsartan combination products; review medication list to avoid therap...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Sacubitril and Valsartan together?

Usually yes, with awareness. Do not co-prescribe separate ARBs with sacubitril/valsartan combination products; review medication list to avoid therapeutic duplication.

What is the severity of this interaction?

The interaction between Sacubitril and Valsartan is classified as Minor — typically manageable. Although marketed as a fixed combination, when prescribed alongside additional valsartan-containing products there is additive angiotensin II receptor blockade and risk of hypotension, hyperkalemia, and renal impairment.

What should I do if I'm prescribed both?

Do not co-prescribe separate ARBs with sacubitril/valsartan combination products; review medication list to avoid therapeutic duplication. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.