Selegiline and Tramadol: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Selegiline and Tramadol unless specifically directed by your doctor.
How Selegiline interacts with Tramadol
Tramadol inhibits serotonin and noradrenaline reuptake; combined with selegiline's MAO-B (and at higher doses MAO-A) inhibition this risks serotonin syndrome and hypertensive crisis.
What you should do
Avoid tramadol in patients on MAO inhibitors and for 14 days after discontinuation; use an alternative analgesic such as morphine or paracetamol.
Key facts
Severity
Major — avoid combination
Mechanism
Tramadol inhibits serotonin and noradrenaline reuptake; combined with selegiline's MAO-B (and at higher doses MAO-A) inh...
Action
Avoid tramadol in patients on MAO inhibitors and for 14 days after discontinuation; use an alternative analgesic such as...
Frequently asked questions
Can I take Selegiline and Tramadol together?
No — this combination should generally be avoided. Avoid tramadol in patients on MAO inhibitors and for 14 days after discontinuation; use an alternative analgesic such as morphine or paracetamol.
What is the severity of this interaction?
The interaction between Selegiline and Tramadol is classified as Major — avoid combination. Tramadol inhibits serotonin and noradrenaline reuptake; combined with selegiline's MAO-B (and at higher doses MAO-A) inhibition this risks serotonin syndrome and hypertensive crisis.
What should I do if I'm prescribed both?
Avoid tramadol in patients on MAO inhibitors and for 14 days after discontinuation; use an alternative analgesic such as morphine or paracetamol. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.