Selegiline and Venlafaxine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Selegiline and Venlafaxine unless specifically directed by your doctor.
How Selegiline interacts with Venlafaxine
Selegiline irreversibly inhibits MAO-B (and MAO-A at higher doses); combined with the SNRI venlafaxine this can cause serotonin syndrome and hypertensive crisis.
What you should do
Avoid combination. Discontinue venlafaxine at least 7 days before starting selegiline and wait 14 days after selegiline before restarting venlafaxine.
Key facts
Severity
Major — avoid combination
Mechanism
Selegiline irreversibly inhibits MAO-B (and MAO-A at higher doses); combined with the SNRI venlafaxine this can cause se...
Action
Avoid combination. Discontinue venlafaxine at least 7 days before starting selegiline and wait 14 days after selegiline ...
Frequently asked questions
Can I take Selegiline and Venlafaxine together?
No — this combination should generally be avoided. Avoid combination. Discontinue venlafaxine at least 7 days before starting selegiline and wait 14 days after selegiline before restarting venlafaxine.
What is the severity of this interaction?
The interaction between Selegiline and Venlafaxine is classified as Major — avoid combination. Selegiline irreversibly inhibits MAO-B (and MAO-A at higher doses); combined with the SNRI venlafaxine this can cause serotonin syndrome and hypertensive crisis.
What should I do if I'm prescribed both?
Avoid combination. Discontinue venlafaxine at least 7 days before starting selegiline and wait 14 days after selegiline before restarting venlafaxine. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.