Ssris and Tramadol: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ssris and Tramadol unless specifically directed by your doctor.
How Ssris interacts with Tramadol
Tramadol inhibits serotonin reuptake and lowers seizure threshold; combination with SSRIs raises risks of serotonin syndrome and seizures.
What you should do
Avoid if possible; if combined, use lowest effective tramadol dose and counsel patient on signs of serotonin syndrome and seizures.
Key facts
Severity
Major — avoid combination
Mechanism
Tramadol inhibits serotonin reuptake and lowers seizure threshold; combination with SSRIs raises risks of serotonin synd...
Action
Avoid if possible; if combined, use lowest effective tramadol dose and counsel patient on signs of serotonin syndrome an...
Frequently asked questions
Can I take Ssris and Tramadol together?
No — this combination should generally be avoided. Avoid if possible; if combined, use lowest effective tramadol dose and counsel patient on signs of serotonin syndrome and seizures.
What is the severity of this interaction?
The interaction between Ssris and Tramadol is classified as Major — avoid combination. Tramadol inhibits serotonin reuptake and lowers seizure threshold; combination with SSRIs raises risks of serotonin syndrome and seizures.
What should I do if I'm prescribed both?
Avoid if possible; if combined, use lowest effective tramadol dose and counsel patient on signs of serotonin syndrome and seizures. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.