Sotalol and Terfenadine: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Sotalol and Terfenadine unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Sotalol interacts with Terfenadine

Both drugs can prolong cardiac repolarization and the QT interval. Additive electrophysiological effects increase risk of torsades de pointes.

What you should do

Avoid combination. Use a non-QT-prolonging antihistamine alternative.

Key facts

Severity

Major — avoid combination

Mechanism

Both drugs can prolong cardiac repolarization and the QT interval. Additive electrophysiological effects increase risk o...

Action

Avoid combination. Use a non-QT-prolonging antihistamine alternative.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Sotalol and Terfenadine together?

No — this combination should generally be avoided. Avoid combination. Use a non-QT-prolonging antihistamine alternative.

What is the severity of this interaction?

The interaction between Sotalol and Terfenadine is classified as Major — avoid combination. Both drugs can prolong cardiac repolarization and the QT interval. Additive electrophysiological effects increase risk of torsades de pointes.

What should I do if I'm prescribed both?

Avoid combination. Use a non-QT-prolonging antihistamine alternative. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.