Rasagiline and Tramadol: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Rasagiline and Tramadol unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Rasagiline interacts with Tramadol

Rasagiline (selective MAO-B inhibitor) loses selectivity at higher doses; tramadol increases serotonin via reuptake inhibition, risking serotonin syndrome.

What you should do

Avoid combination. Use paracetamol, NSAID, or codeine for analgesia in patients on MAO-B inhibitors.

Key facts

Severity

Major — avoid combination

Mechanism

Rasagiline (selective MAO-B inhibitor) loses selectivity at higher doses; tramadol increases serotonin via reuptake inhi...

Action

Avoid combination. Use paracetamol, NSAID, or codeine for analgesia in patients on MAO-B inhibitors.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Rasagiline and Tramadol together?

No — this combination should generally be avoided. Avoid combination. Use paracetamol, NSAID, or codeine for analgesia in patients on MAO-B inhibitors.

What is the severity of this interaction?

The interaction between Rasagiline and Tramadol is classified as Major — avoid combination. Rasagiline (selective MAO-B inhibitor) loses selectivity at higher doses; tramadol increases serotonin via reuptake inhibition, risking serotonin syndrome.

What should I do if I'm prescribed both?

Avoid combination. Use paracetamol, NSAID, or codeine for analgesia in patients on MAO-B inhibitors. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.