Sildenafil and Terazosin: Drug Interaction Guide

Quick answer: This combination requires caution. Sildenafil and Terazosin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Sildenafil interacts with Terazosin

Sildenafil increases cyclic GMP-mediated vasodilation, while terazosin blocks alpha-1-mediated vascular tone. Additive vasodilation can cause symptomatic hypotension or syncope.

What you should do

Ensure alpha-blocker therapy is stable before starting sildenafil. Use low initial sildenafil doses and counsel patients about postural symptoms.

Key facts

Severity

Moderate — caution required

Mechanism

Sildenafil increases cyclic GMP-mediated vasodilation, while terazosin blocks alpha-1-mediated vascular tone. Additive v...

Action

Ensure alpha-blocker therapy is stable before starting sildenafil. Use low initial sildenafil doses and counsel patients...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Sildenafil and Terazosin together?

With caution. Ensure alpha-blocker therapy is stable before starting sildenafil. Use low initial sildenafil doses and counsel patients about postural symptoms.

What is the severity of this interaction?

The interaction between Sildenafil and Terazosin is classified as Moderate — caution required. Sildenafil increases cyclic GMP-mediated vasodilation, while terazosin blocks alpha-1-mediated vascular tone. Additive vasodilation can cause symptomatic hypotension or syncope.

What should I do if I'm prescribed both?

Ensure alpha-blocker therapy is stable before starting sildenafil. Use low initial sildenafil doses and counsel patients about postural symptoms. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.