Tranylcypromine and Tyramine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Tranylcypromine and Tyramine unless specifically directed by your doctor.
How Tranylcypromine interacts with Tyramine
Tranylcypromine irreversibly inhibits monoamine oxidase A in the gut and liver, allowing dietary tyramine to enter the circulation and trigger massive noradrenaline release.
What you should do
Counsel patients to strictly avoid tyramine-rich foods (aged cheese, cured meats, fermented soy, draught beer) during MAOI therapy and for 2 weeks afterwards.
Key facts
Severity
Major — avoid combination
Mechanism
Tranylcypromine irreversibly inhibits monoamine oxidase A in the gut and liver, allowing dietary tyramine to enter the c...
Action
Counsel patients to strictly avoid tyramine-rich foods (aged cheese, cured meats, fermented soy, draught beer) during MA...
Frequently asked questions
Can I take Tranylcypromine and Tyramine together?
No — this combination should generally be avoided. Counsel patients to strictly avoid tyramine-rich foods (aged cheese, cured meats, fermented soy, draught beer) during MAOI therapy and for 2 weeks afterwards.
What is the severity of this interaction?
The interaction between Tranylcypromine and Tyramine is classified as Major — avoid combination. Tranylcypromine irreversibly inhibits monoamine oxidase A in the gut and liver, allowing dietary tyramine to enter the circulation and trigger massive noradrenaline release.
What should I do if I'm prescribed both?
Counsel patients to strictly avoid tyramine-rich foods (aged cheese, cured meats, fermented soy, draught beer) during MAOI therapy and for 2 weeks afterwards. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.