Tranylcypromine and Venlafaxine: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Tranylcypromine and Venlafaxine unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Tranylcypromine interacts with Venlafaxine

Combination of a non-selective MAO inhibitor with a serotonin-noradrenaline reuptake inhibitor causes excessive synaptic serotonin and risk of life-threatening serotonin syndrome.

What you should do

Contraindicated; allow at least 14 days washout after MAOI discontinuation before starting venlafaxine, and 7 days after stopping venlafaxine before MAOI.

Key facts

Severity

Major — avoid combination

Mechanism

Combination of a non-selective MAO inhibitor with a serotonin-noradrenaline reuptake inhibitor causes excessive synaptic...

Action

Contraindicated; allow at least 14 days washout after MAOI discontinuation before starting venlafaxine, and 7 days after...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Tranylcypromine and Venlafaxine together?

No — this combination should generally be avoided. Contraindicated; allow at least 14 days washout after MAOI discontinuation before starting venlafaxine, and 7 days after stopping venlafaxine before MAOI.

What is the severity of this interaction?

The interaction between Tranylcypromine and Venlafaxine is classified as Major — avoid combination. Combination of a non-selective MAO inhibitor with a serotonin-noradrenaline reuptake inhibitor causes excessive synaptic serotonin and risk of life-threatening serotonin syndrome.

What should I do if I'm prescribed both?

Contraindicated; allow at least 14 days washout after MAOI discontinuation before starting venlafaxine, and 7 days after stopping venlafaxine before MAOI. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.