Pseudoephedrine and Tranylcypromine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Pseudoephedrine and Tranylcypromine unless specifically directed by your doctor.
How Pseudoephedrine interacts with Tranylcypromine
Monoamine oxidase inhibition prevents breakdown of noradrenaline released by indirect sympathomimetics, precipitating hypertensive crisis.
What you should do
Contraindicated combination; avoid all indirect sympathomimetics including pseudoephedrine and phenylephrine during and for 2 weeks after MAOI therapy.
Key facts
Severity
Major — avoid combination
Mechanism
Monoamine oxidase inhibition prevents breakdown of noradrenaline released by indirect sympathomimetics, precipitating hy...
Action
Contraindicated combination; avoid all indirect sympathomimetics including pseudoephedrine and phenylephrine during and ...
Frequently asked questions
Can I take Pseudoephedrine and Tranylcypromine together?
No — this combination should generally be avoided. Contraindicated combination; avoid all indirect sympathomimetics including pseudoephedrine and phenylephrine during and for 2 weeks after MAOI therapy.
What is the severity of this interaction?
The interaction between Pseudoephedrine and Tranylcypromine is classified as Major — avoid combination. Monoamine oxidase inhibition prevents breakdown of noradrenaline released by indirect sympathomimetics, precipitating hypertensive crisis.
What should I do if I'm prescribed both?
Contraindicated combination; avoid all indirect sympathomimetics including pseudoephedrine and phenylephrine during and for 2 weeks after MAOI therapy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.