Aliskiren and Lisinopril: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Aliskiren and Lisinopril unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Aliskiren interacts with Lisinopril

Dual blockade of the renin-angiotensin-aldosterone system increases the risk of hyperkalemia, hypotension, and renal impairment.

What you should do

Contraindicated in patients with diabetes or moderate-to-severe renal impairment. Avoid routine combination and choose monotherapy with monitoring.

Key facts

Severity

Major — avoid combination

Mechanism

Dual blockade of the renin-angiotensin-aldosterone system increases the risk of hyperkalemia, hypotension, and renal imp...

Action

Contraindicated in patients with diabetes or moderate-to-severe renal impairment. Avoid routine combination and choose m...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Aliskiren and Lisinopril together?

No — this combination should generally be avoided. Contraindicated in patients with diabetes or moderate-to-severe renal impairment. Avoid routine combination and choose monotherapy with monitoring.

What is the severity of this interaction?

The interaction between Aliskiren and Lisinopril is classified as Major — avoid combination. Dual blockade of the renin-angiotensin-aldosterone system increases the risk of hyperkalemia, hypotension, and renal impairment.

What should I do if I'm prescribed both?

Contraindicated in patients with diabetes or moderate-to-severe renal impairment. Avoid routine combination and choose monotherapy with monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.