Lisinopril and Sacubitril Valsartan: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Lisinopril and Sacubitril Valsartan unless specifically directed by your doctor.
How Lisinopril interacts with Sacubitril Valsartan
Concurrent ACE inhibition and neprilysin inhibition raise bradykinin levels, dramatically increasing risk of angioedema.
What you should do
Contraindicated; allow at least a 36-hour washout between switching from an ACE inhibitor to sacubitril-valsartan.
Key facts
Severity
Major — avoid combination
Mechanism
Concurrent ACE inhibition and neprilysin inhibition raise bradykinin levels, dramatically increasing risk of angioedema.
Action
Contraindicated; allow at least a 36-hour washout between switching from an ACE inhibitor to sacubitril-valsartan.
Frequently asked questions
Can I take Lisinopril and Sacubitril Valsartan together?
No — this combination should generally be avoided. Contraindicated; allow at least a 36-hour washout between switching from an ACE inhibitor to sacubitril-valsartan.
What is the severity of this interaction?
The interaction between Lisinopril and Sacubitril Valsartan is classified as Major — avoid combination. Concurrent ACE inhibition and neprilysin inhibition raise bradykinin levels, dramatically increasing risk of angioedema.
What should I do if I'm prescribed both?
Contraindicated; allow at least a 36-hour washout between switching from an ACE inhibitor to sacubitril-valsartan. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.