Lisinopril and Sacubitril: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Lisinopril and Sacubitril unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Lisinopril interacts with Sacubitril

ACE inhibition from lisinopril and neprilysin inhibition from sacubitril both increase bradykinin-mediated angioedema risk. Combined use is contraindicated because of potentially life-threatening angioedema.

What you should do

Do not co-administer. Allow a 36-hour washout when switching between an ACE inhibitor and sacubitril-valsartan.

Key facts

Severity

Major — avoid combination

Mechanism

ACE inhibition from lisinopril and neprilysin inhibition from sacubitril both increase bradykinin-mediated angioedema ri...

Action

Do not co-administer. Allow a 36-hour washout when switching between an ACE inhibitor and sacubitril-valsartan.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Lisinopril and Sacubitril together?

No — this combination should generally be avoided. Do not co-administer. Allow a 36-hour washout when switching between an ACE inhibitor and sacubitril-valsartan.

What is the severity of this interaction?

The interaction between Lisinopril and Sacubitril is classified as Major — avoid combination. ACE inhibition from lisinopril and neprilysin inhibition from sacubitril both increase bradykinin-mediated angioedema risk. Combined use is contraindicated because of potentially life-threatening angioedema.

What should I do if I'm prescribed both?

Do not co-administer. Allow a 36-hour washout when switching between an ACE inhibitor and sacubitril-valsartan. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.