Alprazolam and Clarithromycin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Alprazolam and Clarithromycin unless specifically directed by your doctor.
How Alprazolam interacts with Clarithromycin
Clarithromycin strongly inhibits CYP3A4, reducing alprazolam metabolism and increasing benzodiazepine exposure, sedation, and respiratory depression risk.
What you should do
Avoid the combination when possible. Use an alternative antibiotic or a benzodiazepine not primarily metabolized by CYP3A4, with close monitoring if unavoidable.
Key facts
Severity
Major — avoid combination
Mechanism
Clarithromycin strongly inhibits CYP3A4, reducing alprazolam metabolism and increasing benzodiazepine exposure, sedation...
Action
Avoid the combination when possible. Use an alternative antibiotic or a benzodiazepine not primarily metabolized by CYP3...
Frequently asked questions
Can I take Alprazolam and Clarithromycin together?
No — this combination should generally be avoided. Avoid the combination when possible. Use an alternative antibiotic or a benzodiazepine not primarily metabolized by CYP3A4, with close monitoring if unavoidable.
What is the severity of this interaction?
The interaction between Alprazolam and Clarithromycin is classified as Major — avoid combination. Clarithromycin strongly inhibits CYP3A4, reducing alprazolam metabolism and increasing benzodiazepine exposure, sedation, and respiratory depression risk.
What should I do if I'm prescribed both?
Avoid the combination when possible. Use an alternative antibiotic or a benzodiazepine not primarily metabolized by CYP3A4, with close monitoring if unavoidable. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.