Alprazolam and Oxycodone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Alprazolam and Oxycodone unless specifically directed by your doctor.
How Alprazolam interacts with Oxycodone
Benzodiazepine GABA-A receptor modulation and opioid mu-receptor agonism produce additive central nervous system and respiratory depression.
What you should do
Avoid routine co-prescribing. If unavoidable, use the lowest effective doses for the shortest duration, counsel about sedation, and consider naloxone provision.
Key facts
Severity
Major — avoid combination
Mechanism
Benzodiazepine GABA-A receptor modulation and opioid mu-receptor agonism produce additive central nervous system and res...
Action
Avoid routine co-prescribing. If unavoidable, use the lowest effective doses for the shortest duration, counsel about se...
Frequently asked questions
Can I take Alprazolam and Oxycodone together?
No — this combination should generally be avoided. Avoid routine co-prescribing. If unavoidable, use the lowest effective doses for the shortest duration, counsel about sedation, and consider naloxone provision.
What is the severity of this interaction?
The interaction between Alprazolam and Oxycodone is classified as Major — avoid combination. Benzodiazepine GABA-A receptor modulation and opioid mu-receptor agonism produce additive central nervous system and respiratory depression.
What should I do if I'm prescribed both?
Avoid routine co-prescribing. If unavoidable, use the lowest effective doses for the shortest duration, counsel about sedation, and consider naloxone provision. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.