Alprazolam and Ritonavir: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Alprazolam and Ritonavir unless specifically directed by your doctor.
How Alprazolam interacts with Ritonavir
Ritonavir strongly inhibits CYP3A4, the main metabolic pathway for alprazolam. This can markedly increase alprazolam exposure and cause excessive sedation, respiratory depression, and psychomotor impairment.
What you should do
Avoid the combination where possible. If a benzodiazepine is required, use an alternative less dependent on CYP3A4 such as lorazepam, oxazepam, or temazepam.
Key facts
Severity
Major — avoid combination
Mechanism
Ritonavir strongly inhibits CYP3A4, the main metabolic pathway for alprazolam. This can markedly increase alprazolam exp...
Action
Avoid the combination where possible. If a benzodiazepine is required, use an alternative less dependent on CYP3A4 such ...
Frequently asked questions
Can I take Alprazolam and Ritonavir together?
No — this combination should generally be avoided. Avoid the combination where possible. If a benzodiazepine is required, use an alternative less dependent on CYP3A4 such as lorazepam, oxazepam, or temazepam.
What is the severity of this interaction?
The interaction between Alprazolam and Ritonavir is classified as Major — avoid combination. Ritonavir strongly inhibits CYP3A4, the main metabolic pathway for alprazolam. This can markedly increase alprazolam exposure and cause excessive sedation, respiratory depression, and psychomotor impairment.
What should I do if I'm prescribed both?
Avoid the combination where possible. If a benzodiazepine is required, use an alternative less dependent on CYP3A4 such as lorazepam, oxazepam, or temazepam. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.