Amiodarone and Citalopram: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Amiodarone and Citalopram unless specifically directed by your doctor.
How Amiodarone interacts with Citalopram
Both drugs prolong the QT interval through cardiac potassium-channel effects, increasing the risk of torsades de pointes and sudden cardiac death.
What you should do
Avoid concurrent use and select an antidepressant with lower QT-prolonging potential. If unavoidable, correct electrolytes and perform baseline and follow-up ECG monitoring.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs prolong the QT interval through cardiac potassium-channel effects, increasing the risk of torsades de pointes...
Action
Avoid concurrent use and select an antidepressant with lower QT-prolonging potential. If unavoidable, correct electrolyt...
Frequently asked questions
Can I take Amiodarone and Citalopram together?
No — this combination should generally be avoided. Avoid concurrent use and select an antidepressant with lower QT-prolonging potential. If unavoidable, correct electrolytes and perform baseline and follow-up ECG monitoring.
What is the severity of this interaction?
The interaction between Amiodarone and Citalopram is classified as Major — avoid combination. Both drugs prolong the QT interval through cardiac potassium-channel effects, increasing the risk of torsades de pointes and sudden cardiac death.
What should I do if I'm prescribed both?
Avoid concurrent use and select an antidepressant with lower QT-prolonging potential. If unavoidable, correct electrolytes and perform baseline and follow-up ECG monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.