Amiodarone and Fluconazole: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Amiodarone and Fluconazole unless specifically directed by your doctor.
How Amiodarone interacts with Fluconazole
Both drugs prolong cardiac repolarization through potassium-channel effects, while fluconazole may also inhibit CYP3A4-mediated amiodarone metabolism.
What you should do
Avoid the combination because of torsades de pointes risk. If unavoidable, correct electrolytes and undertake close ECG and clinical monitoring.
Key facts
Severity
Major — avoid combination
Mechanism
Both drugs prolong cardiac repolarization through potassium-channel effects, while fluconazole may also inhibit CYP3A4-m...
Action
Avoid the combination because of torsades de pointes risk. If unavoidable, correct electrolytes and undertake close ECG ...
Frequently asked questions
Can I take Amiodarone and Fluconazole together?
No — this combination should generally be avoided. Avoid the combination because of torsades de pointes risk. If unavoidable, correct electrolytes and undertake close ECG and clinical monitoring.
What is the severity of this interaction?
The interaction between Amiodarone and Fluconazole is classified as Major — avoid combination. Both drugs prolong cardiac repolarization through potassium-channel effects, while fluconazole may also inhibit CYP3A4-mediated amiodarone metabolism.
What should I do if I'm prescribed both?
Avoid the combination because of torsades de pointes risk. If unavoidable, correct electrolytes and undertake close ECG and clinical monitoring. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.