Citalopram and Fluconazole: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Citalopram and Fluconazole unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Citalopram interacts with Fluconazole

Fluconazole inhibits CYP2C19, increasing citalopram concentrations. Both drugs can also contribute to QT interval prolongation.

What you should do

Avoid when possible or limit citalopram dose and monitor ECG and electrolytes in patients with QT risk factors.

Key facts

Severity

Major — avoid combination

Mechanism

Fluconazole inhibits CYP2C19, increasing citalopram concentrations. Both drugs can also contribute to QT interval prolon...

Action

Avoid when possible or limit citalopram dose and monitor ECG and electrolytes in patients with QT risk factors.

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Citalopram and Fluconazole together?

No — this combination should generally be avoided. Avoid when possible or limit citalopram dose and monitor ECG and electrolytes in patients with QT risk factors.

What is the severity of this interaction?

The interaction between Citalopram and Fluconazole is classified as Major — avoid combination. Fluconazole inhibits CYP2C19, increasing citalopram concentrations. Both drugs can also contribute to QT interval prolongation.

What should I do if I'm prescribed both?

Avoid when possible or limit citalopram dose and monitor ECG and electrolytes in patients with QT risk factors. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.