Amlodipine and Ciclosporin: Drug Interaction Guide

Quick answer: This combination requires caution. Amlodipine and Ciclosporin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Amlodipine interacts with Ciclosporin

Ciclosporin inhibits CYP3A4 metabolism of amlodipine, increasing plasma levels and risk of hypotension and peripheral oedema.

What you should do

Initiate amlodipine at low dose (2.5 mg) and titrate cautiously. Monitor blood pressure and watch for oedema; consider alternative antihypertensive.

Key facts

Severity

Moderate — caution required

Mechanism

Ciclosporin inhibits CYP3A4 metabolism of amlodipine, increasing plasma levels and risk of hypotension and peripheral oe...

Action

Initiate amlodipine at low dose (2.5 mg) and titrate cautiously. Monitor blood pressure and watch for oedema; consider a...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Amlodipine and Ciclosporin together?

With caution. Initiate amlodipine at low dose (2.5 mg) and titrate cautiously. Monitor blood pressure and watch for oedema; consider alternative antihypertensive.

What is the severity of this interaction?

The interaction between Amlodipine and Ciclosporin is classified as Moderate — caution required. Ciclosporin inhibits CYP3A4 metabolism of amlodipine, increasing plasma levels and risk of hypotension and peripheral oedema.

What should I do if I'm prescribed both?

Initiate amlodipine at low dose (2.5 mg) and titrate cautiously. Monitor blood pressure and watch for oedema; consider alternative antihypertensive. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.