Apalutamide and Apixaban: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Apalutamide and Apixaban unless specifically directed by your doctor.
How Apalutamide interacts with Apixaban
Apalutamide strongly induces CYP3A4 and induces P-glycoprotein, potentially lowering apixaban concentrations and reducing anticoagulant efficacy.
What you should do
Avoid concurrent use. Select an anticoagulant whose exposure can be reliably monitored or is not substantially affected by strong enzyme induction.
Key facts
Severity
Major — avoid combination
Mechanism
Apalutamide strongly induces CYP3A4 and induces P-glycoprotein, potentially lowering apixaban concentrations and reducin...
Action
Avoid concurrent use. Select an anticoagulant whose exposure can be reliably monitored or is not substantially affected ...
Frequently asked questions
Can I take Apalutamide and Apixaban together?
No — this combination should generally be avoided. Avoid concurrent use. Select an anticoagulant whose exposure can be reliably monitored or is not substantially affected by strong enzyme induction.
What is the severity of this interaction?
The interaction between Apalutamide and Apixaban is classified as Major — avoid combination. Apalutamide strongly induces CYP3A4 and induces P-glycoprotein, potentially lowering apixaban concentrations and reducing anticoagulant efficacy.
What should I do if I'm prescribed both?
Avoid concurrent use. Select an anticoagulant whose exposure can be reliably monitored or is not substantially affected by strong enzyme induction. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.