Apixaban and Clarithromycin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Apixaban and Clarithromycin unless specifically directed by your doctor.
How Apixaban interacts with Clarithromycin
Clarithromycin is a strong CYP3A4 and P-glycoprotein inhibitor, increasing apixaban plasma concentration and bleeding risk by approximately 60%.
What you should do
Avoid combination if possible. If unavoidable in patients with normal renal function, consider apixaban dose reduction and monitor for bleeding signs.
Key facts
Severity
Major — avoid combination
Mechanism
Clarithromycin is a strong CYP3A4 and P-glycoprotein inhibitor, increasing apixaban plasma concentration and bleeding ri...
Action
Avoid combination if possible. If unavoidable in patients with normal renal function, consider apixaban dose reduction a...
Frequently asked questions
Can I take Apixaban and Clarithromycin together?
No — this combination should generally be avoided. Avoid combination if possible. If unavoidable in patients with normal renal function, consider apixaban dose reduction and monitor for bleeding signs.
What is the severity of this interaction?
The interaction between Apixaban and Clarithromycin is classified as Major — avoid combination. Clarithromycin is a strong CYP3A4 and P-glycoprotein inhibitor, increasing apixaban plasma concentration and bleeding risk by approximately 60%.
What should I do if I'm prescribed both?
Avoid combination if possible. If unavoidable in patients with normal renal function, consider apixaban dose reduction and monitor for bleeding signs. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.