Atorvastatin and Fusidic Acid: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Atorvastatin and Fusidic Acid unless specifically directed by your doctor.
How Atorvastatin interacts with Fusidic Acid
Systemic fusidic acid inhibits CYP3A4 and OATP1B1 transport of atorvastatin, leading to substantially elevated statin exposure and a documented risk of rhabdomyolysis.
What you should do
Suspend atorvastatin during the course of systemic fusidic acid and for 7 days after the last dose. Counsel patients about myalgia and dark urine.
Key facts
Severity
Major — avoid combination
Mechanism
Systemic fusidic acid inhibits CYP3A4 and OATP1B1 transport of atorvastatin, leading to substantially elevated statin ex...
Action
Suspend atorvastatin during the course of systemic fusidic acid and for 7 days after the last dose. Counsel patients abo...
Frequently asked questions
Can I take Atorvastatin and Fusidic Acid together?
No — this combination should generally be avoided. Suspend atorvastatin during the course of systemic fusidic acid and for 7 days after the last dose. Counsel patients about myalgia and dark urine.
What is the severity of this interaction?
The interaction between Atorvastatin and Fusidic Acid is classified as Major — avoid combination. Systemic fusidic acid inhibits CYP3A4 and OATP1B1 transport of atorvastatin, leading to substantially elevated statin exposure and a documented risk of rhabdomyolysis.
What should I do if I'm prescribed both?
Suspend atorvastatin during the course of systemic fusidic acid and for 7 days after the last dose. Counsel patients about myalgia and dark urine. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.