Atorvastatin and Gemfibrozil: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Atorvastatin and Gemfibrozil unless specifically directed by your doctor.
How Atorvastatin interacts with Gemfibrozil
Gemfibrozil inhibits OATP1B1 hepatic uptake and CYP2C8/glucuronidation of statins, increasing statin exposure 2-3-fold and substantially raising risk of rhabdomyolysis.
What you should do
Avoid the combination. If a fibrate is required with a statin, use fenofibrate which has substantially lower risk of myopathy.
Key facts
Severity
Major — avoid combination
Mechanism
Gemfibrozil inhibits OATP1B1 hepatic uptake and CYP2C8/glucuronidation of statins, increasing statin exposure 2-3-fold a...
Action
Avoid the combination. If a fibrate is required with a statin, use fenofibrate which has substantially lower risk of myo...
Frequently asked questions
Can I take Atorvastatin and Gemfibrozil together?
No — this combination should generally be avoided. Avoid the combination. If a fibrate is required with a statin, use fenofibrate which has substantially lower risk of myopathy.
What is the severity of this interaction?
The interaction between Atorvastatin and Gemfibrozil is classified as Major — avoid combination. Gemfibrozil inhibits OATP1B1 hepatic uptake and CYP2C8/glucuronidation of statins, increasing statin exposure 2-3-fold and substantially raising risk of rhabdomyolysis.
What should I do if I'm prescribed both?
Avoid the combination. If a fibrate is required with a statin, use fenofibrate which has substantially lower risk of myopathy. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.