Domperidone and Erythromycin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Domperidone and Erythromycin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Domperidone interacts with Erythromycin

Erythromycin inhibits CYP3A4 metabolism of domperidone and independently prolongs QT interval, producing additive arrhythmogenic risk.

What you should do

Combination is contraindicated per EMA/MHRA guidance; choose an alternative antiemetic and consider azithromycin only if a macrolide is essential.

Key facts

Severity

Major — avoid combination

Mechanism

Erythromycin inhibits CYP3A4 metabolism of domperidone and independently prolongs QT interval, producing additive arrhyt...

Action

Combination is contraindicated per EMA/MHRA guidance; choose an alternative antiemetic and consider azithromycin only if...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Domperidone and Erythromycin together?

No — this combination should generally be avoided. Combination is contraindicated per EMA/MHRA guidance; choose an alternative antiemetic and consider azithromycin only if a macrolide is essential.

What is the severity of this interaction?

The interaction between Domperidone and Erythromycin is classified as Major — avoid combination. Erythromycin inhibits CYP3A4 metabolism of domperidone and independently prolongs QT interval, producing additive arrhythmogenic risk.

What should I do if I'm prescribed both?

Combination is contraindicated per EMA/MHRA guidance; choose an alternative antiemetic and consider azithromycin only if a macrolide is essential. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.