Carvedilol and Ciclosporin: Drug Interaction Guide

Quick answer: This combination requires caution. Carvedilol and Ciclosporin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Carvedilol interacts with Ciclosporin

Carvedilol inhibits P-glycoprotein-mediated efflux of ciclosporin, raising ciclosporin trough concentrations by approximately 20%.

What you should do

Monitor ciclosporin trough levels closely after initiating, adjusting, or stopping carvedilol; reduce ciclosporin dose if levels rise.

Key facts

Severity

Moderate — caution required

Mechanism

Carvedilol inhibits P-glycoprotein-mediated efflux of ciclosporin, raising ciclosporin trough concentrations by approxim...

Action

Monitor ciclosporin trough levels closely after initiating, adjusting, or stopping carvedilol; reduce ciclosporin dose i...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Carvedilol and Ciclosporin together?

With caution. Monitor ciclosporin trough levels closely after initiating, adjusting, or stopping carvedilol; reduce ciclosporin dose if levels rise.

What is the severity of this interaction?

The interaction between Carvedilol and Ciclosporin is classified as Moderate — caution required. Carvedilol inhibits P-glycoprotein-mediated efflux of ciclosporin, raising ciclosporin trough concentrations by approximately 20%.

What should I do if I'm prescribed both?

Monitor ciclosporin trough levels closely after initiating, adjusting, or stopping carvedilol; reduce ciclosporin dose if levels rise. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.