Carvedilol and Cyclosporine: Drug Interaction Guide

Quick answer: This combination requires caution. Carvedilol and Cyclosporine can be used together with adjustments and monitoring.

How Carvedilol interacts with Cyclosporine

Carvedilol inhibits P-glycoprotein-mediated efflux of cyclosporine, increasing cyclosporine trough concentrations by 10-20%.

What you should do

Monitor cyclosporine trough levels when starting or adjusting carvedilol and reduce cyclosporine dose if levels exceed target.

Key facts

Severity

Moderate — caution required

Mechanism

Carvedilol inhibits P-glycoprotein-mediated efflux of cyclosporine, increasing cyclosporine trough concentrations by 10-...

Action

Monitor cyclosporine trough levels when starting or adjusting carvedilol and reduce cyclosporine dose if levels exceed t...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Carvedilol and Cyclosporine together?

With caution. Monitor cyclosporine trough levels when starting or adjusting carvedilol and reduce cyclosporine dose if levels exceed target.

What is the severity of this interaction?

The interaction between Carvedilol and Cyclosporine is classified as Moderate — caution required. Carvedilol inhibits P-glycoprotein-mediated efflux of cyclosporine, increasing cyclosporine trough concentrations by 10-20%.

What should I do if I'm prescribed both?

Monitor cyclosporine trough levels when starting or adjusting carvedilol and reduce cyclosporine dose if levels exceed target. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: May 15, 2026 by iMedic Medical Editorial Team. Our editorial process.