Ciclosporin and Clarithromycin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Ciclosporin and Clarithromycin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Ciclosporin interacts with Clarithromycin

Clarithromycin inhibits CYP3A4 and P-glycoprotein, substantially increasing ciclosporin exposure and the risk of nephrotoxicity and neurotoxicity.

What you should do

Avoid combination when possible; use azithromycin as alternative. If unavoidable, reduce ciclosporin dose and monitor trough levels and renal function closely.

Key facts

Severity

Major — avoid combination

Mechanism

Clarithromycin inhibits CYP3A4 and P-glycoprotein, substantially increasing ciclosporin exposure and the risk of nephrot...

Action

Avoid combination when possible; use azithromycin as alternative. If unavoidable, reduce ciclosporin dose and monitor tr...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ciclosporin and Clarithromycin together?

No — this combination should generally be avoided. Avoid combination when possible; use azithromycin as alternative. If unavoidable, reduce ciclosporin dose and monitor trough levels and renal function closely.

What is the severity of this interaction?

The interaction between Ciclosporin and Clarithromycin is classified as Major — avoid combination. Clarithromycin inhibits CYP3A4 and P-glycoprotein, substantially increasing ciclosporin exposure and the risk of nephrotoxicity and neurotoxicity.

What should I do if I'm prescribed both?

Avoid combination when possible; use azithromycin as alternative. If unavoidable, reduce ciclosporin dose and monitor trough levels and renal function closely. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.