Clarithromycin and Nifedipine: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Clarithromycin and Nifedipine unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Clarithromycin interacts with Nifedipine

Clarithromycin inhibits CYP3A4 metabolism of nifedipine, increasing calcium-channel blocker exposure. This can cause hypotension, flushing, acute kidney injury, or shock in vulnerable patients.

What you should do

Prefer a non-macrolide antibiotic or azithromycin where appropriate; monitor blood pressure and renal function if coadministration cannot be avoided.

Key facts

Severity

Major — avoid combination

Mechanism

Clarithromycin inhibits CYP3A4 metabolism of nifedipine, increasing calcium-channel blocker exposure. This can cause hyp...

Action

Prefer a non-macrolide antibiotic or azithromycin where appropriate; monitor blood pressure and renal function if coadmi...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Clarithromycin and Nifedipine together?

No — this combination should generally be avoided. Prefer a non-macrolide antibiotic or azithromycin where appropriate; monitor blood pressure and renal function if coadministration cannot be avoided.

What is the severity of this interaction?

The interaction between Clarithromycin and Nifedipine is classified as Major — avoid combination. Clarithromycin inhibits CYP3A4 metabolism of nifedipine, increasing calcium-channel blocker exposure. This can cause hypotension, flushing, acute kidney injury, or shock in vulnerable patients.

What should I do if I'm prescribed both?

Prefer a non-macrolide antibiotic or azithromycin where appropriate; monitor blood pressure and renal function if coadministration cannot be avoided. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.