Clarithromycin and Pimozide: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Clarithromycin and Pimozide unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Clarithromycin interacts with Pimozide

Clarithromycin inhibits CYP3A4 metabolism of pimozide, leading to elevated levels that prolong QT interval and risk torsades de pointes.

What you should do

Combination is contraindicated. Use azithromycin or non-macrolide antibiotic; consider alternative antipsychotic if macrolide essential.

Key facts

Severity

Major — avoid combination

Mechanism

Clarithromycin inhibits CYP3A4 metabolism of pimozide, leading to elevated levels that prolong QT interval and risk tors...

Action

Combination is contraindicated. Use azithromycin or non-macrolide antibiotic; consider alternative antipsychotic if macr...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Clarithromycin and Pimozide together?

No — this combination should generally be avoided. Combination is contraindicated. Use azithromycin or non-macrolide antibiotic; consider alternative antipsychotic if macrolide essential.

What is the severity of this interaction?

The interaction between Clarithromycin and Pimozide is classified as Major — avoid combination. Clarithromycin inhibits CYP3A4 metabolism of pimozide, leading to elevated levels that prolong QT interval and risk torsades de pointes.

What should I do if I'm prescribed both?

Combination is contraindicated. Use azithromycin or non-macrolide antibiotic; consider alternative antipsychotic if macrolide essential. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.