Clopidogrel and Rosuvastatin: Drug Interaction Guide
Quick answer: This combination requires caution. Clopidogrel and Rosuvastatin can be used together with adjustments and monitoring.
How Clopidogrel interacts with Rosuvastatin
Clopidogrel and its acyl glucuronide metabolite inhibit OATP1B1, increasing rosuvastatin exposure approximately 2-fold and elevating myopathy risk.
What you should do
Limit rosuvastatin to 20 mg daily when used with clopidogrel and monitor for muscle symptoms or unexplained CK elevations.
Key facts
Severity
Moderate — caution required
Mechanism
Clopidogrel and its acyl glucuronide metabolite inhibit OATP1B1, increasing rosuvastatin exposure approximately 2-fold a...
Action
Limit rosuvastatin to 20 mg daily when used with clopidogrel and monitor for muscle symptoms or unexplained CK elevation...
Frequently asked questions
Can I take Clopidogrel and Rosuvastatin together?
With caution. Limit rosuvastatin to 20 mg daily when used with clopidogrel and monitor for muscle symptoms or unexplained CK elevations.
What is the severity of this interaction?
The interaction between Clopidogrel and Rosuvastatin is classified as Moderate — caution required. Clopidogrel and its acyl glucuronide metabolite inhibit OATP1B1, increasing rosuvastatin exposure approximately 2-fold and elevating myopathy risk.
What should I do if I'm prescribed both?
Limit rosuvastatin to 20 mg daily when used with clopidogrel and monitor for muscle symptoms or unexplained CK elevations. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.