Lopinavir and Rosuvastatin: Drug Interaction Guide

Quick answer: This combination requires caution. Lopinavir and Rosuvastatin can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Lopinavir interacts with Rosuvastatin

Lopinavir/ritonavir inhibits OATP1B1 transporters that mediate hepatic uptake of rosuvastatin, increasing rosuvastatin AUC about 2-fold with risk of myopathy.

What you should do

Start with rosuvastatin 5 mg and do not exceed 10 mg daily in patients on lopinavir/ritonavir; monitor for muscle symptoms and CK.

Key facts

Severity

Moderate — caution required

Mechanism

Lopinavir/ritonavir inhibits OATP1B1 transporters that mediate hepatic uptake of rosuvastatin, increasing rosuvastatin A...

Action

Start with rosuvastatin 5 mg and do not exceed 10 mg daily in patients on lopinavir/ritonavir; monitor for muscle sympto...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Lopinavir and Rosuvastatin together?

With caution. Start with rosuvastatin 5 mg and do not exceed 10 mg daily in patients on lopinavir/ritonavir; monitor for muscle symptoms and CK.

What is the severity of this interaction?

The interaction between Lopinavir and Rosuvastatin is classified as Moderate — caution required. Lopinavir/ritonavir inhibits OATP1B1 transporters that mediate hepatic uptake of rosuvastatin, increasing rosuvastatin AUC about 2-fold with risk of myopathy.

What should I do if I'm prescribed both?

Start with rosuvastatin 5 mg and do not exceed 10 mg daily in patients on lopinavir/ritonavir; monitor for muscle symptoms and CK. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.