Colchicine and Erythromycin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Colchicine and Erythromycin unless specifically directed by your doctor.
How Colchicine interacts with Erythromycin
Erythromycin inhibits CYP3A4 and P-glycoprotein, markedly increasing colchicine plasma levels with risk of fatal toxicity (multi-organ failure, myelosuppression).
What you should do
Contraindicated in renal or hepatic impairment. In normal organ function, reduce colchicine dose substantially and limit duration.
Key facts
Severity
Major — avoid combination
Mechanism
Erythromycin inhibits CYP3A4 and P-glycoprotein, markedly increasing colchicine plasma levels with risk of fatal toxicit...
Action
Contraindicated in renal or hepatic impairment. In normal organ function, reduce colchicine dose substantially and limit...
Frequently asked questions
Can I take Colchicine and Erythromycin together?
No — this combination should generally be avoided. Contraindicated in renal or hepatic impairment. In normal organ function, reduce colchicine dose substantially and limit duration.
What is the severity of this interaction?
The interaction between Colchicine and Erythromycin is classified as Major — avoid combination. Erythromycin inhibits CYP3A4 and P-glycoprotein, markedly increasing colchicine plasma levels with risk of fatal toxicity (multi-organ failure, myelosuppression).
What should I do if I'm prescribed both?
Contraindicated in renal or hepatic impairment. In normal organ function, reduce colchicine dose substantially and limit duration. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.