Cyclosporine and Erythromycin: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Cyclosporine and Erythromycin unless specifically directed by your doctor.
How Cyclosporine interacts with Erythromycin
Erythromycin inhibits CYP3A4 and P-glycoprotein, increasing cyclosporine concentrations. Nephrotoxicity and other concentration-related toxicity may occur.
What you should do
Avoid or use an alternative macrolide; if unavoidable, monitor cyclosporine trough levels and renal function.
Key facts
Severity
Major — avoid combination
Mechanism
Erythromycin inhibits CYP3A4 and P-glycoprotein, increasing cyclosporine concentrations. Nephrotoxicity and other concen...
Action
Avoid or use an alternative macrolide; if unavoidable, monitor cyclosporine trough levels and renal function.
Frequently asked questions
Can I take Cyclosporine and Erythromycin together?
No — this combination should generally be avoided. Avoid or use an alternative macrolide; if unavoidable, monitor cyclosporine trough levels and renal function.
What is the severity of this interaction?
The interaction between Cyclosporine and Erythromycin is classified as Major — avoid combination. Erythromycin inhibits CYP3A4 and P-glycoprotein, increasing cyclosporine concentrations. Nephrotoxicity and other concentration-related toxicity may occur.
What should I do if I'm prescribed both?
Avoid or use an alternative macrolide; if unavoidable, monitor cyclosporine trough levels and renal function. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.