Amlodipine and Diltiazem: Drug Interaction Guide

Quick answer: This combination requires caution. Amlodipine and Diltiazem can be used together with adjustments and monitoring.

How Amlodipine interacts with Diltiazem

Diltiazem inhibits CYP3A4 metabolism of amlodipine, increasing exposure and additive vasodilatory and negative inotropic effects.

What you should do

Avoid routine combination. If used together, start at low doses and monitor blood pressure, heart rate, and for peripheral edema.

Key facts

Severity

Moderate — caution required

Mechanism

Diltiazem inhibits CYP3A4 metabolism of amlodipine, increasing exposure and additive vasodilatory and negative inotropic...

Action

Avoid routine combination. If used together, start at low doses and monitor blood pressure, heart rate, and for peripher...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Amlodipine and Diltiazem together?

With caution. Avoid routine combination. If used together, start at low doses and monitor blood pressure, heart rate, and for peripheral edema.

What is the severity of this interaction?

The interaction between Amlodipine and Diltiazem is classified as Moderate — caution required. Diltiazem inhibits CYP3A4 metabolism of amlodipine, increasing exposure and additive vasodilatory and negative inotropic effects.

What should I do if I'm prescribed both?

Avoid routine combination. If used together, start at low doses and monitor blood pressure, heart rate, and for peripheral edema. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: May 17, 2026 by iMedic Medical Editorial Team. Our editorial process.