Linezolid and Trazodone: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Linezolid and Trazodone unless specifically directed by your doctor.
How Linezolid interacts with Trazodone
Linezolid is a reversible monoamine oxidase inhibitor, and trazodone increases serotonergic neurotransmission. Combined use can precipitate serotonin syndrome.
What you should do
Avoid unless no alternatives exist. If essential, stop serotonergic therapy when clinically feasible and monitor closely for serotonin toxicity.
Key facts
Severity
Major — avoid combination
Mechanism
Linezolid is a reversible monoamine oxidase inhibitor, and trazodone increases serotonergic neurotransmission. Combined ...
Action
Avoid unless no alternatives exist. If essential, stop serotonergic therapy when clinically feasible and monitor closely...
Frequently asked questions
Can I take Linezolid and Trazodone together?
No — this combination should generally be avoided. Avoid unless no alternatives exist. If essential, stop serotonergic therapy when clinically feasible and monitor closely for serotonin toxicity.
What is the severity of this interaction?
The interaction between Linezolid and Trazodone is classified as Major — avoid combination. Linezolid is a reversible monoamine oxidase inhibitor, and trazodone increases serotonergic neurotransmission. Combined use can precipitate serotonin syndrome.
What should I do if I'm prescribed both?
Avoid unless no alternatives exist. If essential, stop serotonergic therapy when clinically feasible and monitor closely for serotonin toxicity. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.