Sacubitril Valsartan and Trandolapril: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Sacubitril Valsartan and Trandolapril unless specifically directed by your doctor.
How Sacubitril Valsartan interacts with Trandolapril
Combining neprilysin inhibition with ACE inhibition increases bradykinin accumulation. This substantially increases angioedema risk.
What you should do
Do not use sacubitril-valsartan with an ACE inhibitor. Allow an appropriate washout period when switching.
Key facts
Severity
Major — avoid combination
Mechanism
Combining neprilysin inhibition with ACE inhibition increases bradykinin accumulation. This substantially increases angi...
Action
Do not use sacubitril-valsartan with an ACE inhibitor. Allow an appropriate washout period when switching.
Frequently asked questions
Can I take Sacubitril Valsartan and Trandolapril together?
No — this combination should generally be avoided. Do not use sacubitril-valsartan with an ACE inhibitor. Allow an appropriate washout period when switching.
What is the severity of this interaction?
The interaction between Sacubitril Valsartan and Trandolapril is classified as Major — avoid combination. Combining neprilysin inhibition with ACE inhibition increases bradykinin accumulation. This substantially increases angioedema risk.
What should I do if I'm prescribed both?
Do not use sacubitril-valsartan with an ACE inhibitor. Allow an appropriate washout period when switching. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.