Ramipril and Sacubitril Valsartan: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Ramipril and Sacubitril Valsartan unless specifically directed by your doctor.
How Ramipril interacts with Sacubitril Valsartan
Concurrent ACE inhibition and neprilysin inhibition raise bradykinin levels markedly, increasing risk of severe angioedema.
What you should do
Contraindicated. Allow at least 36 hours washout between stopping ramipril and starting sacubitril-valsartan.
Key facts
Severity
Major — avoid combination
Mechanism
Concurrent ACE inhibition and neprilysin inhibition raise bradykinin levels markedly, increasing risk of severe angioede...
Action
Contraindicated. Allow at least 36 hours washout between stopping ramipril and starting sacubitril-valsartan.
Frequently asked questions
Can I take Ramipril and Sacubitril Valsartan together?
No — this combination should generally be avoided. Contraindicated. Allow at least 36 hours washout between stopping ramipril and starting sacubitril-valsartan.
What is the severity of this interaction?
The interaction between Ramipril and Sacubitril Valsartan is classified as Major — avoid combination. Concurrent ACE inhibition and neprilysin inhibition raise bradykinin levels markedly, increasing risk of severe angioedema.
What should I do if I'm prescribed both?
Contraindicated. Allow at least 36 hours washout between stopping ramipril and starting sacubitril-valsartan. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.