Ergotamine and Erythromycin: Drug Interaction Guide

Quick answer: This is a major interaction — avoid combining Ergotamine and Erythromycin unless specifically directed by your doctor.

Interaction severity: Major — avoid combination

How Ergotamine interacts with Erythromycin

Erythromycin inhibits CYP3A4 metabolism of ergotamine, leading to ergot accumulation and severe vasospasm (ergotism) with risk of peripheral ischaemia.

What you should do

Contraindicated. Use alternative antibiotic (azithromycin, doxycycline) or alternative migraine therapy. Stop ergotamine before macrolide treatment.

Key facts

Severity

Major — avoid combination

Mechanism

Erythromycin inhibits CYP3A4 metabolism of ergotamine, leading to ergot accumulation and severe vasospasm (ergotism) wit...

Action

Contraindicated. Use alternative antibiotic (azithromycin, doxycycline) or alternative migraine therapy. Stop ergotamine...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Ergotamine and Erythromycin together?

No — this combination should generally be avoided. Contraindicated. Use alternative antibiotic (azithromycin, doxycycline) or alternative migraine therapy. Stop ergotamine before macrolide treatment.

What is the severity of this interaction?

The interaction between Ergotamine and Erythromycin is classified as Major — avoid combination. Erythromycin inhibits CYP3A4 metabolism of ergotamine, leading to ergot accumulation and severe vasospasm (ergotism) with risk of peripheral ischaemia.

What should I do if I'm prescribed both?

Contraindicated. Use alternative antibiotic (azithromycin, doxycycline) or alternative migraine therapy. Stop ergotamine before macrolide treatment. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.