Erythromycin and Ivabradine: Drug Interaction Guide
Quick answer: This is a major interaction — avoid combining Erythromycin and Ivabradine unless specifically directed by your doctor.
How Erythromycin interacts with Ivabradine
Erythromycin inhibits CYP3A4, substantially increasing ivabradine exposure. Excess ivabradine can cause marked bradycardia and conduction disturbances.
What you should do
Avoid co-administration. Use a non-macrolide antibiotic or temporarily withhold ivabradine if clinically appropriate.
Key facts
Severity
Major — avoid combination
Mechanism
Erythromycin inhibits CYP3A4, substantially increasing ivabradine exposure. Excess ivabradine can cause marked bradycard...
Action
Avoid co-administration. Use a non-macrolide antibiotic or temporarily withhold ivabradine if clinically appropriate.
Frequently asked questions
Can I take Erythromycin and Ivabradine together?
No — this combination should generally be avoided. Avoid co-administration. Use a non-macrolide antibiotic or temporarily withhold ivabradine if clinically appropriate.
What is the severity of this interaction?
The interaction between Erythromycin and Ivabradine is classified as Major — avoid combination. Erythromycin inhibits CYP3A4, substantially increasing ivabradine exposure. Excess ivabradine can cause marked bradycardia and conduction disturbances.
What should I do if I'm prescribed both?
Avoid co-administration. Use a non-macrolide antibiotic or temporarily withhold ivabradine if clinically appropriate. Always consult your prescribing clinician — do not stop or change medications without medical guidance.
Last reviewed: by iMedic Medical Editorial Team. Our editorial process.