Escitalopram and Omeprazole: Drug Interaction Guide

Quick answer: This combination requires caution. Escitalopram and Omeprazole can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Escitalopram interacts with Omeprazole

Omeprazole inhibits CYP2C19, the principal metabolic enzyme for escitalopram, increasing plasma concentrations and the risk of QT prolongation.

What you should do

Limit escitalopram dose to 10 mg daily in patients receiving omeprazole and consider baseline and follow-up ECG in those with cardiac risk factors.

Key facts

Severity

Moderate — caution required

Mechanism

Omeprazole inhibits CYP2C19, the principal metabolic enzyme for escitalopram, increasing plasma concentrations and the r...

Action

Limit escitalopram dose to 10 mg daily in patients receiving omeprazole and consider baseline and follow-up ECG in those...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Escitalopram and Omeprazole together?

With caution. Limit escitalopram dose to 10 mg daily in patients receiving omeprazole and consider baseline and follow-up ECG in those with cardiac risk factors.

What is the severity of this interaction?

The interaction between Escitalopram and Omeprazole is classified as Moderate — caution required. Omeprazole inhibits CYP2C19, the principal metabolic enzyme for escitalopram, increasing plasma concentrations and the risk of QT prolongation.

What should I do if I'm prescribed both?

Limit escitalopram dose to 10 mg daily in patients receiving omeprazole and consider baseline and follow-up ECG in those with cardiac risk factors. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.