Omeprazole and Posaconazole: Drug Interaction Guide

Quick answer: This combination requires caution. Omeprazole and Posaconazole can be used together with adjustments and monitoring.

Interaction severity: Moderate — caution required

How Omeprazole interacts with Posaconazole

Omeprazole increases gastric pH, which can reduce absorption of some posaconazole formulations, particularly oral suspension. Lower posaconazole exposure may compromise antifungal prophylaxis or treatment.

What you should do

Avoid unnecessary acid suppression and use delayed-release tablets or intravenous posaconazole when appropriate. Consider therapeutic drug monitoring in high-risk patients.

Key facts

Severity

Moderate — caution required

Mechanism

Omeprazole increases gastric pH, which can reduce absorption of some posaconazole formulations, particularly oral suspen...

Action

Avoid unnecessary acid suppression and use delayed-release tablets or intravenous posaconazole when appropriate. Conside...

Important medical disclaimer: This page provides educational information about drug interactions for general reference. It is not a substitute for professional medical advice, diagnosis, or treatment. Always discuss your specific medications with a qualified healthcare provider before starting, stopping, or changing any treatment. About our editorial team.

Frequently asked questions

Can I take Omeprazole and Posaconazole together?

With caution. Avoid unnecessary acid suppression and use delayed-release tablets or intravenous posaconazole when appropriate. Consider therapeutic drug monitoring in high-risk patients.

What is the severity of this interaction?

The interaction between Omeprazole and Posaconazole is classified as Moderate — caution required. Omeprazole increases gastric pH, which can reduce absorption of some posaconazole formulations, particularly oral suspension. Lower posaconazole exposure may compromise antifungal prophylaxis or treatment.

What should I do if I'm prescribed both?

Avoid unnecessary acid suppression and use delayed-release tablets or intravenous posaconazole when appropriate. Consider therapeutic drug monitoring in high-risk patients. Always consult your prescribing clinician — do not stop or change medications without medical guidance.

Last reviewed: by iMedic Medical Editorial Team. Our editorial process.